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A short insight into RDW by dr.Ashutosh ????? ( AIIMS )

INTRODUCTION:- Red blood cell distribution width (RDW or RDW-CV or RCDW and RDW-SD) is a measure of the range of variation of red blood cell (RBC) volume that is reported as part of a standard complete blood count. wedding garments for older and mature brides over 40/50

???????? Usually red blood cells are a standard size of about 6-8 ?m in diameter

...

. Certain disorders, however, cause a significant variation in cell size. Higher RDW values indicate greater variation in size

. Normal reference range of RDW-CV in human red blood cells is 11.5-14.5%.

???????? If anemia is observed, RDW test results are often used together with mean corpuscular volume (MCV) results to determine the possible causes of the anemia.

???????? It is mainly used to differentiate an anemia of mixed causes from an anemia of a single cause. ????

???????? Friends before going into pathologucal implications of RDW- SD

JUST MAKE ONE THING CLEAR IN UR MINDS

???????? VIT B12 / IRON AND FOLIC ACID all three are strongly interelated ???? ???? ( deficiency or excess of one seriously effects the other two) ????

Now lets proceed ???? ???????? ???????? ???????? ???????? ???????? ????????

RDW = Red blood cell distribution width

???????? RDW- CV = ( STANDARD DEVIATION OF MCV /MEAN MCV ) X100

???????? Pathological implications of RDW

???? Normal RDW

1) Thalassemia ( only anemia where RDW is normal ) ????

???? HIGH RDW

1) IDA ( IRON DEFICIENCY ANEMIA ) ????

???? characteristic property of IDA IS High RDW / NORMAL MCV / Spoon shaped nails / cigar shaped cells ( pencil shaped cells ) ???? ???? ???? ???? ???? ????

2) Folate and Vitamin B 12 deficiency anemia is characterised by

???????? HIGH RDW AND HIGH MCV ???? ???? ????

3) MIXED DEFICIENCY ( IRON + VITAMIN B12 / FOLATE ) usually characterised by

???????? HIGH RDW WITH MCV HIGH / LOW / NORMAL ???? ????

4 ) Recent hemorrhage present with following characteristics

???????? HIGH RDW WITH NORMAL MCV ( JUST LIKE IN IDA ) ???? ????

???? FALSE + ve RDW can occur if EDTA ( an anticoagulant ) is used instead of citrate ???? ( AIIMS PGMEE 2010) ????

Thanks n regards

Dr.Ashutosh mishra

AIIMS

IMMUNOLOGY DEPARTMENT

NEW DELHI

110019

INDIA

+91

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